Further studies on the lactic acid, sugar and inorganic phosphorus of the blood of ruminants, (a) following adrenalectomy and (b) after intravenous injection of insulin

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Abstract
Surgical technique for adrenalectomy operations on sheep is described. After bilateral adrenalectomy the lactic acid and sugar levels of the blood were markedly lowered while inorganic P was considerably increased. No change occurred in any of the 3 blood constituents when the adrenalectomized sheep were subjected to such types of excitement and muscular exercise as were known to alter them in normal sheep. Injection of insulin caused no definite changes in blood lactic acid; the degree of hypoglycemia produced in intact animals was somewhat smaller than in the case of other mammals and no convulsions were observed even after large doses. Changes in blood phosphate corresponded to those observed in other animals. Bilateral adrenalectomy appeared to increase the sensitivity of the sheep to insulin, since hypoglycemic convulsions appeared after a small dose.

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