Design and synthesis of N-(N-((S)-1-ethoxycarbonyl-3-phenylpropyl)-L-alanyl)-N-(indan-2-yl)glycine (CV-3317), a new, potent angiotensin converting enzyme inhibitor.
- 1 January 1986
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 34 (7) , 2852-2858
- https://doi.org/10.1248/cpb.34.2852
Abstract
A new angiotensin converting enzyme (ACE) inhibitor, N-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-N-(indan-2-yl)glycine (9a), was found as a result of extensive studies on the structural requisites for the C-terminal amino acid moiety in ACE inhibitors. The synthesis and the determination of the absolute configuration of 9a are described.This publication has 7 references indexed in Scilit:
- Angiotensin converting enzyme inhibitors: 1-glutarylindoline-2-carboxylic acid derivativesJournal of Medicinal Chemistry, 1983
- Angiotensin converting enzyme inhibitors: N-Substituted monocyclic and bicyclic amino acid derivativesJournal of Medicinal Chemistry, 1983
- (Mercaptopropanoyl)indoline-2-carboxylic acids and related compounds as potent angiotensin converting enzyme inhibitors and antihypertensive agentsJournal of Medicinal Chemistry, 1983
- A new class of angiotensin-converting enzyme inhibitorsNature, 1980
- Design of Specific Inhibitors of Angiotensin-Converting Enzyme: New Class of Orally Active Antihypertensive AgentsScience, 1977
- Amino acids and peptides. XXVI. Phosphorus in organic synthesis. XV. Application of diphenyl phosphorazidate (DPPA) and diethyl phosphorocyanidate (DEPC) to the synthesis of the N-terminal decapeptide of gastric inhibitory polypeptide.CHEMICAL & PHARMACEUTICAL BULLETIN, 1977
- Phosphorus in organic synthesis—XI Amino acids and peptides—XXITetrahedron, 1976