Macrolide-ResistantShigella sonnei

Open Access

1 August 2008

journal article
case report
Published by Centers for Disease Control and Prevention (CDC) in Emerging Infectious Diseases

Vol. 14 (8) , 1297-1299
https://doi.org/10.3201/eid1408.080147

Abstract

Shigella sonnei UCN59, isolated during an outbreak of S. sonnei in January 2007, was resistant to azithromycin (MIC 64 mg/L). The isolate contained a plasmid-borne mph(A) gene encoding a macrolide 2′-phosphotransferase that inactivates macrolides. Emergence of the mph(A) gene in S. sonnei may limit usefulness of azithromycin for treatment of shigellosis.

Keywords

This publication has 14 references indexed in Scilit:

Outbreaks of multidrug-resistant Shigella sonnei gastroenteritis associated with day care centers--Kansas, Kentucky, and Missouri, 2005.
2006
A recurring outbreak of Shigella sonnei among traditionally observant Jewish children in New York City: the risks of daycare and household transmission
Epidemiology and Infection, 2006
Antimicrobial-Resistant Shigella sonnei
The Pediatric Infectious Disease Journal, 2005
Microbial DNA Typing by Automated Repetitive-Sequence-Based PCR
Journal of Clinical Microbiology, 2005
Food-Related Illness and Death in the United States
Emerging Infectious Diseases, 1999
A prolonged outbreak of Shigella sonnei infections in traditionally observant Jewish communities in North America caused by a molecularly distinct bacterial subtype.
The Journal of Infectious Diseases, 1998
Treatment of Shigellosis: V. Comparison of Azithromycin and Ciprofloxacin: A Double-Blind, Randomized, Controlled Trial
Annals of Internal Medicine, 1997
Nucleotide sequence and characterization of erythromycin resistance determinant that encodes macrolide 2'-phosphotransferase I in Escherichia coli
Antimicrobial Agents and Chemotherapy, 1995
In vitro activity of azithromycin against bacterial enteric pathogens
Antimicrobial Agents and Chemotherapy, 1993
In vitro and in vivo uptake of azithromycin (CP-62,993) by phagocytic cells: possible mechanism of delivery and release at sites of infection
Antimicrobial Agents and Chemotherapy, 1989