Flare‐up reactions and desensitization from oral dosing in chromate‐sensitive guinea pigs
- 1 May 1984
- journal article
- research article
- Published by Wiley in Contact Dermatitis
- Vol. 10 (5) , 277-279
- https://doi.org/10.1111/j.1600-0536.1984.tb00146.x
Abstract
Flare‐up reactions were induced in potassium dichromate hypersensitive guinea pigs by a single oral dose of 55 mg/kg. This dose is systemically toxic and higher than the dose required to induce the same reactions in humans. A total oral dose of potassium dichromate of 90‐115 mg/kg induced immunological unresponsiveness for at least 6 weeks. With limitations, the guinea pig model maybe helpful in screening the hyposensitization capacity of different haptens dosed orally.Keywords
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