Neuropsychiatric Manifestations of Patients With Cushing's Syndrome
- 1 February 1981
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 141 (2) , 215-219
- https://doi.org/10.1001/archinte.1981.00340020077021
Abstract
• Thirty-five consecutive patients with Cushing's syndrome were studied prospectively before treatment. A consistent constellation of neuropsychiatric disturbances was found, including impairments in affect (depressed mood and crying), cognitive functions (decreased concentration and memory), and vegetative functions (decreased libido and insomnia). Thirty-four percent of patients were rated as having a mild, 26% a moderate, 29% a severe, and 11% a very severe psychiatric disability. A statistically significant relationship was found between the overall neuropsychiatric disability rating and cortisol and adrenocorticotropic hormone (ACTH) levels. Patients with adrenal adenomas with high cortisol but low ACTH levels did not have as severe a neuropsychiatric disability. (Arch Intern Med141:215-219, 1981)This publication has 1 reference indexed in Scilit:
- Common precursor to corticotropins and endorphinsProceedings of the National Academy of Sciences, 1977