BLOCKADE OF SOME CARDIAC ACTIONS OF ADRENALINE BY DICHLOROISOPROTERENOL

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Abstract
Dichloroisoproterenol (DCI) has been found to produce a competitive blockade of the positive inotropic action of adrenaline on cat papillary muscles. The effect of adrenaline on electrical excitability of this preparation also is blocked. DCI itself has been shown to have considerable adrenaline-like activity, increasing the strength of contraction and decreasing the threshold of electrical excitability. The positive chronotropic and arrhythmia-inducing effects of adrenaline have been shown to be blocked in the whole animal.