SUPPRESSION OF STEROID DIABETES BY WALKER CARCINOMA IN THE RAT

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Abstract
Male Sprague-Dawley rats were tube-fed a medium carbohydrate diet twice daily. Steroid diabetes was induced by subcutaneous injection of cortisone acetate each morning. Implantation of Walker Carcinoma 256 into each groin was followed by marked suppression of glycosuria after the tumor began to grow. The growth of tumor was suppressed in proportion to the dose of cortisone. At the end of 10 days the average weight of tumor in rats without cortisone was 25.2 gm.; in similar rats given 15 mg. of cortisone daily the average weight of tumor was 3.31 gm., and the average amount of glucose excreted on the 10th day was 0.61 gm. In rats without tumor given 15 mg. of cortisone daily the average amount of glucose excreted on the 10th day was 5.68 gm. In some tumor hosts the glycosuria disappeared as the tumor grew slowly. Cortisone acetate (15 mg. daily) was tested in animals with established tumors. After tumor growth for 12 days and longer glycosuria could no longer be induced by the steroid. When rats with steroid diabetes were stressed by the excision of skin there was a moderate suppression of glycosuria.

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