Demonstration of gene dosage effects on antigens in the Duffy, Ss, and Rh systems using an enzyme‐linked immunosorbent assay

Publisher Website
Google Scholar
Abstract
Using a recently developed enzyme-linked immunosorbent assay, gene dosage effects were demonstrated for the Duffy, Ss and Rh [human] red blood cell antigen systems. A comparison by an antibody-binding assay of the relative amounts of Fya and Fyb antigens on FyaFya, FyaFyb, FybFyb, FyaFyx and FyxFyx erythrocytes, and of s antigen on cells homozygous and heterozygous for s is reported. The immunosorbent assay also was used to study Rh antigens, and data which was obtained using radiolabeled antibodies were confirmed.