Antithrombotic Agents and Thromboembolic Disease

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Abstract
Among patients undergoing elective hip replacement, the incidence of deep-vein thrombosis in the absence of prophylactic anticoagulation approaches 50 percent.1,2 Thrombus formation is multifocal, occurring principally in the surgically manipulated leg, where trauma to blood vessels and venous stasis would be expected to be most severe. Since approximately half of thrombi are found in large proximal veins, the risk of pulmonary embolism is high. An optimal therapeutic regimen should therefore be capable of preventing the initiation and propagation of venous thrombi without increasing the risk of perioperative bleeding or interfering with wound healing.The efficacy of several pharmacologic agents, . . .

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