Level of Human Chorionic Gonadotrop in-Like Substance in Serum of Normal Subjects

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Abstract
The level of human chorionic gonadotropin (hCG)-like substance in normal serum was measured using 50 .mu.l of serum specimen by a highly specific and sensitive sandwich enzyme immunoassay for hCG which did not significantly cross-react with hLH [luteinizing hormone]. The level was calculated using a standard hCG and expressed in mIU/ml as that of hCG. In normal male (20-59 yr of age) and normal, non-pregnant female (20-42 yr of age) adults, the level was below 0.6 mIU/ml with mean levels of 0.16 mIU/ml (n = 209) and 0.14 mIU/ml (n = 36), respectively. In older subjects, however, the level tended to rise. In normal male adults, aged 60-91 yr, the level was mostly below 0.8 mIU/ml (mean = 0.56 mIU/ml, n = 99), but levels of 15 specimens out of 99 were 1.1-5.5 mIU/ml. In normal, non-pregnant female adults, aged 45-88 yr, the level was widely distributed between 0.1 and 11.7 mIU/ml (mean = 1.6 mIU/ml, n = 141). In these older female adults, levels of hCG-like substance were not well correlated to either levels of hLH and hFSH, while levels of hLH and hFSH were well correlated to each other.

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