Release from maternally-induced allotypic suppression in rabbit by Nocardia water-soluble mitogen.
Open Access
- 1 September 1977
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 146 (3) , 881-886
- https://doi.org/10.1084/jem.146.3.881
Abstract
The in vitro synthesis of allotypes of b4/b5 offspring obtained from b4/b4 mothers immunized against paternal allotype b5/b5 was studied in comparison to similar offspring that had escaped from suppression and normal heterozygous b4/b5 rabbits. Nocardia water-soluble mitogen-a rabbit B-cell mitogen which is known to induce the differentiation of small lymphocytes into plasma cells and polyclonal activation of Ig, was able to break in vitro the allotypic suppression induced in vivo.This publication has 16 references indexed in Scilit:
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