STUDIES ON DIPETALONEMA-VITEAE (FILARIOIDEA) .4. PASSIVE TRANSFER OF IMMUNITY TO CIRCULATING MICROFILARIAE BY SPLEEN-CELLS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 30  (3) , 371-375
Abstract
Passive transfer experiments demonstrated a role of spleen cells in immunity of hamsters against D. viteae microfilariae. Spleen cells (.gtoreq. 106) from post-patent (amicrofilaremic) hamsters suppressed incipient microfilaremia in syngeneic recipients when transferred at wk 2 or 6 of a primary infection. Spleen cells from microfilaremic donors (wk 15-16 post-infection) could transfer immunity against microfilariae. The spleen at cell transfer never affected the survival of adult worm. After transfer of spleen cell from patent or postpatent hamsters, antibodies to the cuticle of microfilariae could be found in the sera of recipients at wk 8 of primary infection.