LIQUID‐LIQUID EXTRACTION IN PEPTIDE SYNTHESIS
- 1 May 1980
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 15 (5) , 411-419
- https://doi.org/10.1111/j.1399-3011.1980.tb02916.x
Abstract
An efficient procedure of peptide synthesis in solution based on liquid-liquid extraction for the purification of intermediates (2-phase method) is described. Peptide segments of 10 and in favorable cases 15 amino acids can be prepared by using conventional blocking groups. Special blocking groups adapted for optimal performance are discussed. Simple equipment enabling rapid synthesis is described.Keywords
This publication has 18 references indexed in Scilit:
- SYNTHESIS OF CARBOXYL TERMINAL SEGMENTS OF BETA‐SUBUNIT OF HUMAN CHORIONIC GONADOTROPINInternational Journal of Peptide and Protein Research, 1980
- SYNTHESIS OF GRANULIBERIN R. AN APPLICATION OF THE ‘HOLD-IN-SOLUTION’ METHODChemistry Letters, 1977
- A new substrate for enteropeptidaseFEBS Letters, 1976
- Synthesis of the Gastrointestinal Peptide Hormone Secretin by the Repetitive Excess Mixed Anhydride (REMA) MethodHelvetica Chimica Acta, 1976
- o-Nitrophenyl esters of benzyloxycarbonylamino acids and their application in the synthesis of peptide chains by the in situ techniqueThe Journal of Organic Chemistry, 1974
- Schnellverfahren zur “Liquid‐Phase”‐Peptidsynthese: Die KristallisationsmethodeAngewandte Chemie, 1974
- Antigen Synthesis: The Preparation of Selected Dodecapeptide Carriers with Systematically Altered Structures by a Two‐Phase MethodHelvetica Chimica Acta, 1972
- A Rapid Synthesis of Oligopeptide Derivatives without Isolation of IntermediatesJournal of the American Chemical Society, 1965
- Usefulness of the phthalimidomethyl group for the reversible protection of carboxyl functionsRecueil des Travaux Chimiques des Pays-Bas, 1963
- Über eine Färbemethode zum Anfärben von Aminosäuren, Peptiden und Proteinen auf Papierchromatogrammen und PapierelektropherogrammenEuropean Journal of Inorganic Chemistry, 1954