An Explanation for Increased Interferon Production At Low Multiplicities of Infection

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Abstract
Relatively low multiplicities of Semliki Forest virus induce optimal yields of interferon in chick embryo cell cultures. High multiplicities apparently inhibit interferon synthesis; however, a different mechanism is shown to be responsible. The increase yield of interferon at low multiplicities is shown to be associated with a prolongation of interferon synthesis due to multiple cycles of virus replication. The possibility of interferon induced in the first cycle of replication having a priming effect on interferon production in subsequent cycles is suggested.

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