AMYOTROPHIC LATERAL SCLEROSIS ON GUAM: A CLINICAL STUDY AND REVIEW OF THE LITERATURE
- 1 December 1952
- journal article
- review article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 37 (6) , 1204-1220
- https://doi.org/10.7326/0003-4819-37-6-1204
Abstract
Amyotrophic lateral sclerosis was found to be unusually prevalent on the island of Guam. 35 cases, representing an incidence of 13 per 10,000 native inhabitants, were examined and summaries of 16 other cases were compiled. Unusual aspects of the series include an unusually high familial incidence (40%), a higher incidence of spasm or rigidity, an extremely large number of cases (80%) exhibiting signs of pseudobulbar palsy, and involvement of the spinal accessory nerve in 40%.Keywords
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