Influenza Virus-specific T Cells Lead to Early Interferon in Lungs of Infected Hosts: Development of a Sensitive Radioimmunoassay

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Abstract
A sensitive immunoradiometric assay for murine interferon .gamma. (MuIFN-.gamma.) has been developed and used reproducibly to measure low levels of MuIFN-.gamma. in lung lavage samples from influenza-infected mice. In control infected mice, IFN-.gamma. peaked on day 6, but transfer of virus-specific cytotoxic T cells or T helper cells, which reduced virus replication in vivo in infected hosts, resulted in an earlier peak on day 4.