A novel aspect of calpain activation
Open Access
- 14 August 1998
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 433 (1-2) , 1-4
- https://doi.org/10.1016/s0014-5793(98)00856-4
Abstract
Calpain, a Ca2+‐dependent biomodulator, alters the properties of substrate proteins by cleaving them at a limited number of specific sites. Recent studies of the structure‐function relationship of calpain and X‐ray analysis of its Ca2+‐binding domain have revealed hitherto unknown features of the regulation of calpain activity. A novel dissociation/autolysis mechanism for the activation of calpain at the membrane is proposed, which incorporates recent findings from structure‐function studies of calpain, and its implications are discussed.Keywords
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