EXPERIMENTAL TOXEMIA OF PREGNANCY IN MONKEY, WITH A PRELIMINARY-REPORT ON RENIN AND ALDOSTERONE
- 1 January 1977
- journal article
- research article
- Vol. 86 (3) , 573-590
Abstract
Experimental toxemia of pregnancy was induced in 8 pregnant monkeys (Macaca mulatta) by reducing the abdominal aorta to 1/2 of its original diameter during the last month of gestation. It was characterized by hypertension and proteinuria. In the kidney, light microscopy, and EM immunofluorescence revealed findings similar to those in human toxemia. Focal necrosis in the liver and diffuse hemorrhagic infarctions in the placenta were also observed. Plasma renin activity and aldosterone levels, as determined in blood from the uterine vein, were elevated. None of these changes were found in 4 control animals.This publication has 19 references indexed in Scilit:
- CHANGES IN THE RENIN‐ANGIOTENSIN SYSTEM IN PRIMIGRAVIDAE WITH HYPERTENSIVE DISEASE OF PREGNANCYBJOG: An International Journal of Obstetrics and Gynaecology, 1975
- Toxemia of pregnancy: Mechanism and therapeutic managementThe American Journal of Cardiology, 1973
- PLASMA RENIN, RENIN SUBSTRATE, ANGIOTENSIN II, AND ALDOSTERONE IN HYPERTENSIVE DISEASE OF PREGNANCYThe Lancet, 1973
- Uterine blood flow and uterine renin secretionJournal of Clinical Investigation, 1972
- A Radioimmunoassay for Aldosterone in Human Peripheral Plasma Including a Comparison of Alternate TechniquesJournal of Clinical Endocrinology & Metabolism, 1972
- PLASMA RENIN ACTIVITY IN PERIPHERAL AND UTERINE VEIN BLOOD IN PREGNANT AND NON‐PREGNANT WOMENBJOG: An International Journal of Obstetrics and Gynaecology, 1972
- AN INVESTIGATION OF THE CELLULAR SOURCE OF RENIN IN HUMAN CHORIONBJOG: An International Journal of Obstetrics and Gynaecology, 1970
- Application of a Radioimmunoassay for Angiotensin I to the Physiologic Measurements of Plasma Renin Activity in Normal Human Subjects1Journal of Clinical Endocrinology & Metabolism, 1969
- Glomerular capillary endothelial swelling in a pregnant chimpanzeeAmerican Journal of Obstetrics and Gynecology, 1969
- Aldosterone Secretion Rates in Abnormal Pregnancy1Journal of Clinical Endocrinology & Metabolism, 1965