Versatile Oligonucleotides: B DNA, Z DNA, and DNA Hairpins as Seen in Aqueous Solution by Two-Dimensional NMR
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 6 (1-2) , 157-172
- https://doi.org/10.1080/07328318708056189
Abstract
Approaches to the study of DNA polymorphism by means of NMR spectroscopy are explored. A method is outlined whereby sequence-dependent variations of sugar pucker in the major conformer of DNA duplexes can be investigated in solution. The results are compared with predictions based upon X-ray studies. The formation of hairpin loops in self-complementary DNA oligomers appears more common than thought previously. Some ‘rules of the game’ are discussed.Keywords
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