CD4 lymphocyte subset abnormalities associated with impaired delayed cutaneous hypersensitivity reactions in patients with X-linked agammaglobulinaemia

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Abstract
SUMMARY: Circulating CD4 lymphocyte subset (CD45RA; CD45RO; CD29; Leu8) levels were determined in nine patients with -inked agammaglobulinaemia (XLA), nine patients with common variable immunodeficiency (CVI) and in 18 age– and se-atched controls. CD4CD45RO and CD4CD29 cells were significantly lower (P<001) in the XLA patient group (CD45RO, 15.7·10.2%; CD4CD29, 32.1 ±14.6%) compared with CVI patients (61.8·2504%; 6001 ±11.2%) and normal controls (43.7·22.3%, 54.5·22.0%). The levels of CD4CD45RA and CD4Leu8 cells were not abnormal in the XLA patient group. No selective reduction in CD4 subsets was observed in the CVI patient group. Delayed cutaneous hypersensitivity testing of five XLA and five CVI patients revealed a significantly reduced response to recall antigens in patients with XLA. This may relate to the deficiency of circulating memory T cells observed in these patients.