THE MATURATION OF THE PITUITARY-ADRENAL AXIS IN THE NEWBORN RAT1

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Abstract
The maturation of the pituitary-adrenal axis in the newborn rat The administration of adrenocorticotropic hormone (ACTH) results in an immediate fall in the ascorbic acid and cholesterol concentration of the adult rat and guinea pig adrenal gland (Sayers, Sayers, Fry, White and Long (1944); Sayers, Sayers, Liang and Long (1946)). The decline of ascorbic acid content becomes manifest within an hour after the injection of ACTH. There is also evidence that the fall in concentration of these substances is correlated with adrenal cortical secretion as shown by an increase in liver glycogen and lymphopenia. Selye (1937) had previously demonstrated that the administration of noxious substances resulted in adrenal hypertrophy in normal animals but not in hypophysectomized ones. He postulated that exposure to stress resulted in the release of ACTH by the animal’s pituitary gland. Long and Fry (1945); Sayers and Sayers (1948); Ludewig and Chanutin (1947); Levin (1945) and others have shown that the adadministration of epinephrine,

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