Interaction of Hepatitis B Virus with Cellular Processes in Liver Carcinogenesis
- 1 January 2000
- journal article
- research article
- Published by Taylor & Francis in Critical Reviews in Clinical Laboratory Sciences
- Vol. 37 (5) , 407-429
- https://doi.org/10.1080/10408360091174277
Abstract
Hepatitis B infection is strongly linked epidemiologically to hepatocellular carcinoma development. This article reviews the molecular mechanisms by which hepatitis B encoded proteins such as hepatitis B x and hepatitis B surface transactivators may interact with gene transcription, tumor suppression, apoptosis, and signalling pathways of the liver cell with the possible consequence of tumor induction. Data on the interaction between hepatitis B proteins and cellular processes are often conflicting indicating a non-specific simultaneous interaction with antagonistic cellular processes that result in the formation of escape mutants that are not subject to these selective pressures.Keywords
This publication has 182 references indexed in Scilit:
- Hepatitis B x Protein Inhibits p53-dependent DNA Repair in Primary Mouse HepatocytesJournal of Biological Chemistry, 1998
- Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasomeOncogene, 1998
- Mutation ofp53 gene in hepatocellular carcinoma cell lines with HBX DNAInternational Journal of Cancer, 1996
- Transactivating function and expression of the x gene of hepatitis B virusJournal of Hepatology, 1995
- HBx protein of hepatitis B virus interacts with the C-terminal portion of a novel human proteasome alpha-subunitVirus Genes, 1995
- Point mutations of the P53 gene, human hepatocellular carcinoma and aflatoxinsJournal of Hepatology, 1993
- Full-length and truncated versions of the hepatitis B virus (HBV) X protein (pX) transactivate the cMYC protooncogene at the transcriptional levelBiochemical and Biophysical Research Communications, 1991
- Frequent activation of N-myc genes by hepadnavirus insertion in woodchuck liver tumoursNature, 1990
- Modulation of expression of the hepatitis B virus surface antigen gene by the viralX-gene productProceedings Of The Royal Society B-Biological Sciences, 1990
- A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinomaNature, 1987