Dual-isotope myocardial imaging: feasibility, advantages and limitations

1 March 1994

journal article
Published by Springer Nature in European Journal of Nuclear Medicine and Molecular Imaging

Vol. 21 (3) , 212-215
https://doi.org/10.1007/bf00188668

Abstract

Two hundred and thirty-one patients underwent dual-isotope myocardial imaging (rest thallium-201 followed by stress technetium-99m sestamibi). The feasibility of the procedure was excellent: camera scheduling flexibility was improved and the duration of the procedure was less than that of a classical stress-redistribution procedure. Interpretation of defects due to image attenuation was facilitated by the different attenuation properties of ²⁰¹Tl and ^99mTc-sestamibi in 11 of 19 patients. ²¹⁰Tl cross-over on ^99mTc was found to be 15% ± 3% with doses of ²⁰¹Tl and ^99mTc-sestamibi of 3 and 10 mCi, respectively, and 7% ± 2% with doses of 3 and 20 mCi. This protocol should preferentially be reserved for patients with a history of myocardial infarction and/or a basal left ventricular dysfunction, in whom assessment of myocardial viability is of major interest. Extensive clinical validation of the dual-isotope procedure is required and optimal acquisition and reconstruction parameters should be established.

Keywords

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