N-Acetyl-procainamide kinetics in the elderly

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Abstract
Plasma and saliva N-acetyl-procainamide (NAPA) concentrations were measured by high-power liquid chromatography (HPLC) after i.v. infusion of 750 mg to 14 elderly patients (.hivin.x [mean] age = 69 yr). The plasma NAPA disappearance curve can best be described by a 2-compartment body model. Mean total body clearance was 10.6 l/h, Vdss [steady state volume distribution] 125.8 l and terminal half-life (t1/2) 8.8 h. A nonrenal clearance of 2.72 l/h was calculated, i.e., 19% of the expected total body clearance with normal kidney function. Saliva concentrations show huge inter- and intraindividual variability and are probably not usable for NAPA monitoring in older patients.