Ventricular Arrhythmias and Left Ventricular Dysfunction in Familial Cardiomyopathy

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Abstract
In familial cardiomyopathy (CM), different forms of myocardial abnormalities including asymmetric and symmetric hypertrophy and dilated left ventricles are presented, mostly showing varying hereditary penetrance. A family is presented with CM including 3 major clinical manifestations: severe ventricular arrhythmias, repolarization abnormalitites and left ventricular hypertrophy. This triad was strikingly consistent in the 2 generations examined. The familial pattern with an autosomal dominant inheritance did not show any linkage to the HLA region.