Enhancement of 45Ca2+ Binding to Acidic Lipids by Barbiturates, Diphenylhydantoin, and Ethanol
- 1 May 1981
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 36 (5) , 1865-1867
- https://doi.org/10.1111/j.1471-4159.1981.tb00443.x
Abstract
Effects of barbiturates, diphenylhydantoin, and ethanol on 45Ca2+ binding to acidic lipids have been examined in an organic solvent-aqueous partition system. Hexobarbital, pentobarbital, and phenobarbital, at concentrations of 0.3 and/or 0.6 mM, enhanced the binding of 45Ca2+ to phosphatidic acid, phosphatidylserine, and sulfatide but not to phosphatidylinositol or cardiolipin. Diphenylhydantoin, 0.3 mM, enhanced 45Ca2+ binding to phosphatidic acid and phosphatidylserine but not to sulfatide. Ethanol at 80 mM did not enhance 45Ca2+ binding to phosphatidic acid, but ethanol decreased the binding to cardiolipin and increased it to sulfatide.Keywords
This publication has 13 references indexed in Scilit:
- Effects of acute and chronic ethanol administration on whole mouse brain synaptosomal calcium influxBiochemical Pharmacology, 1980
- Acute and chronic effects of barbiturates on depolarization-induced calcium influx into rat synaptosomesBrain Research, 1980
- Phospholipids as the molecular instruments of ion and solute transport in biological membranes.Proceedings of the National Academy of Sciences, 1980
- Pentobarbital depression of stimulus-secretion coupling in brain— Selective inhibition of depolarization-induced calcium-dependent releaseBiochemical Pharmacology, 1977
- Phospholipids as ion exchangers: Implications for a possible role in biological membrane excitability and anesthesiaBiochimica et Biophysica Acta (BBA) - Biomembranes, 1967
- The Binding of Calcium at Lipid‐Water InterfacesEuropean Journal of Biochemistry, 1967
- Competitive binding of Na, K, Mg and Ca ions to cerebroside sulphuric acidJournal of Neurochemistry, 1965
- Reaction of Local Anesthetics with PhospholipidsThe Journal of general physiology, 1964
- A Molecular Structural Basis for the Excitation Properties of AxonsBiophysical Journal, 1964
- The action of calcium on the electrical properties of squid axonsThe Journal of Physiology, 1957