A STUDY OF THE ORIGIN AND DISTRIBUTION OF THE ANTIGONADOTROPHIC SUBSTANCE IN ANIMALS CHRONICALLY TREATED WITH CRUDE SHEEP PITUITARY EXTRACT1

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Abstract
Lymphocytes collected by cannulation of the thoracic duct of rabbits and homogenates of lymph node, spleen, liver, bone marrow, cecum, and thymus from rats and rabbits treated for prolonged periods with crude sheep pituitary extract gave no evidence of antigonadotrophic activity. Lymph plasma showed almost the same antigonadotrophic titer as the blood serum. Injns. of pituitary extract into the sole of the foot of rats and rabbits did not result in demonstrable amts. of antigonadotrophic substance in homogenates of popliteal and iliac lymph nodes. Adrenal cortical extract and lymph node antiserum did not alter the antigonadotrophic titer of blood serum of immunized animals. Based on the assumption that the antigonadotrophic substance is an antibody, the conclusion is drawn that these findings do not support the view which regards lymphoid tissue in general and the lymphocyte in particular as the source of antibody the release of which is brought about by adrenal cortical substance.

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