Sequence‐specific chemical modification of a hybrid bacteriophage M 13 single‐stranded DNA by alkylating oligonucleotide derivatives

25 April 1988

journal article
Published by Wiley in FEBS Letters

Vol. 231 (2) , 352-354
https://doi.org/10.1016/0014-5793(88)80848-2

Abstract

Alkylating oligonucleotide derivatives react with the complementary sequences in hybrid M 13mp7 bacteriophage single‐stranded DNA and destroy the infecting ability of the DNA. The reagents do not damage M 13mp9 single‐stranded DNA lacking the target nucleotide sequence.

Keywords

NUCLEIC ACID
AFFINITY MODIFICATION
CHEMICAL MODIFICATION

This publication has 2 references indexed in Scilit:

Complementary addressed modification and cleavage of a single stranded DNA fragment with alkylating oligonucleotide derivatives
Nucleic Acids Research, 1986
Sequence‐specific chemical modification of a 365‐nucleotide‐long DNA fragment with an alkylating oligonucleotide derivative
FEBS Letters, 1985