Naturally HIV-1 seroconverters with lowest viral load have best prognosis, but in time lose control of viraemia
- 1 March 2002
- journal article
- research article
- Published by Wolters Kluwer Health in AIDS
- Vol. 16 (5) , 791-793
- https://doi.org/10.1097/00002030-200203290-00016
Abstract
Candidate AIDS vaccines are based on the success of monkey studies, showing the ability of vaccine-induced cytotoxic T lymphocytes to control HIV-1 replication. We evaluated the ability to maintain suppression of virus replication in seroconverters with a naturally low level of plasma HIV-1 RNA. No AIDS-defining events were observed at low plasma HIV-1-RNA levels, but a steady loss of CD4 T lymphocytes occurred, and long-term control of viraemia was extremely rare in the natural course of HIV-1 infectioKeywords
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