The in vitro activity of mezlocillin when combined with cefoxitin or clavulanic acid

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Abstract
Mezlocillin is a potent broad spectrum antimicrobial but is susceptible to a wide range of β-lactamases. In this investigation the combination of cefoxitin and clavulanic acid upon the in vitro activity of mezlocillin was studied. An agar plate dilution method was used. Little significant interaction was seen between cefoxitin and mezlocillin especially against β-lactamase producing Enterobacteriaceae. Some synergy was seen against Bacteroides fragilis. When clavulanic acid was combined with mezlocillin there was marked synergy against β-lactamase producing strains of the Enterobacteriaceae and Staphylococcus aureus tested.

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