REFINED LINKAGE MAP OF CHROMOSOME-7 IN THE REGION OF THE CYSTIC-FIBROSIS GENE
- 1 January 1988
- journal article
- research article
- Vol. 42 (1) , 38-44
Abstract
The genetic map in the region of human chromosome 7 that harbors the gene for cystic fibrosis (CF) has been refined by multilocus linkage studies in an expanded database including a large set of normal families. Six loci known to be linked to CF were examined: MET, an oncogene; COL1A2, collagen; TCRB, T-cell-receptor beta polypeptide; and three arbitrary loci.sbd.D7S8, D7S13, and D7S16.sbd.defined by probes pJ3.11, pB79a, and p7C22, respectively. The gene order with greatest statistical support is COL1A2-D7S13-D7S16-MET-D7S8-TCRB. Linkage analysis in families segregating for CF suggested that the most likely location of the CF gene on this map is between MET and D7S8.This publication has 18 references indexed in Scilit:
- Investigation of Genetic Linkage in Human FamiliesPublished by Springer Nature ,1987
- Linkage of cystic fibrosis to the proα 2(I) collagen gene, COL1A2, on chromosome 7Cytogenetic and Genome Research, 1986
- Highly Polymorphic RFLP Probes as Diagnostic ToolsPublished by Cold Spring Harbor Laboratory ,1986
- LINKAGE OF COL1A2 COLLAGEN GENE TO CYSTIC FIBROSIS, AND ITS CLINICAL IMPLICATIONSThe Lancet, 1985
- Cystic Fibrosis Locus Defined by a Genetically Linked Polymorphic DNA MarkerScience, 1985
- The human met oncogene is related to the tyrosine kinase oncogenesNature, 1985
- Localization of cystic fibrosis locus to human chromosome 7cen–q22Nature, 1985
- A closely linked genetic marker for cystic fibrosisNature, 1985
- A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7Nature, 1985
- Linkage relationships of paraoxonase (PON) with other markers: indication of PON‐cystic fibrosis syntenyClinical Genetics, 1985