Controlled ovarian hyperstimulation with or without intrauterine insemination for the treatment of unexplained infertility
- 1 January 1995
- journal article
- clinical trial
- Published by Wiley in International Journal of Gynecology & Obstetrics
- Vol. 48 (1) , 55-59
- https://doi.org/10.1016/0020-7292(94)02268-2
Abstract
Objective: To evaluate whether there are any benefits from intrauterine insemination (IUI) as opposed to timed intercourse (TI) in stimulated ovarian cycles in couples with longstanding, unexplained infertility. Methods: Forty-six couples with diagnoses of unexplained infertility were evaluated in a crossover study after a total of 141 cycles. Sixty-seven cycles were with IUI after controlled ovarian hyperstimulation (COH) while 74 cycles were after COH and TI. Results: The pregnancy rate after COH/TI was 16.7% and after COH/IUI 45.2%. Cycle fecundity however was 8.9% after COH/TI and 25.7% after COH/IUI, which is a statistically significant difference (P < 0.05). Conclusions: A trial of human menopausal gonadotropin and IUI is justified in couples with prolonged infertility of unknown cause.Keywords
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