The Internal Organization of the Varicella-Zoster Virus Genome
- 1 June 1982
- journal article
- Published by Microbiology Society in Journal of General Virology
- Vol. 60 (2) , 371-374
- https://doi.org/10.1099/0022-1317-60-2-371
Abstract
DNA was extracted from varicella-zoster (VZ) virions prepared in sucrose gradients. Thirty-eight molecules examined by electron microscopy were found to have a mean length of 46.7 micrometers. Examination of self-annealed VZV DNA molecules revealed that the virus genome was composed of a unique linear large sequence with a mol. wt. of 74.4 X 10(6) to 78.4 X 10(6), and a unique short sequence of mol. wt. approx. 9.8 X 10(6) flanked by inverted repeat sequences of 4.7 X 10(6) mol. wt.Keywords
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