Behavioral Effects of Low Doses of DDT

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Abstract
Several behavioral and neurophysiological parameters were altered in mice acutely dosed with low doses of DDT. Open-field exploratory activity was significantly enhanced 24 hours after an oral dose of DDT at 25 mg/kg. Concomitantly, the animals' ability to habituate to the open-field situation was attenuated. In a passive avoidance test DDT, at doses lower than 25 mg/kg, alleviated the stress-induced motor depression. Selected changes in the maximum electroshock seizure pattern reflected an increase in brain excitability. The possibility is advanced that DDT facilitates the central excitatory process, at least partially, by a disinhibitory mechanism.

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