Protective Role of Lung Surfactant Protein D in a Murine Model of Invasive Pulmonary Aspergillosis
Open Access
- 1 April 2001
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 69 (4) , 2728-2731
- https://doi.org/10.1128/iai.69.4.2728-2731.2001
Abstract
The protective effects of intranasal administration of amphotericin B (AmB), human SP-A, SP-D and a 60-kDa fragment of SP-D (rSP-D) were examined in a murine model of invasive pulmonary aspergillosis (IPA). The untreated group of IPA mice showed no survival at 7 days postinfection. Treatment with AmB, SP-D, and rSP-D increased the survival rate to 80, 60, and 80%, respectively, suggesting that SP-D (and rSP-D) can protect immunosuppressed mice from an otherwise fatal challenge with Aspergillus fumigatus conidia.Keywords
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