Nasal Mucosal Mast Cell Degranulation

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Abstract
Human nasal mast cells stimulated to undergo in situ degranulation by reversed or passive anaphylaxis are morphologically distinct from resting (unstimulated) cells and exhibit sequential changes that are enumerable by electron microscopy. The initially amorphous, dense-staining matrix of secretory granules is not extruded during degranulation. Instead, solubilization of the granule matrix results in the sequential evolution of scroll-like, reticular (rope-like), and particulate constituents. Largely degranulated mast cells may lack typical secretory granules and are, therefore, identifiable only by high power electron microscopy.

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