Effect of ethanol preexposure on ethanol-induced conditioned taste aversion.

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Abstract
During a 21-day period, 37 male Holtzman albino rats received different schedules of intubated ethanol, intubated sucrose and water while a control group of 8 rats received isocaloric sucrose intubations and water. On day 22 and every 3rd day thereafter until day 37, all animals were allowed 30 min of access to a 0.1% sodium-saccharin solution instead of water, followed immediately by intubation with 6 g of ethanol per kg. The animals'' aversion to saccharin, measured by their consumption of the fluid, was a function of preexposure to ethanol: the control group showed the greatest aversion; the 16 rats that had 14 days of ethanol intubations, ending a week before the taste aversion test, showed slightly less aversion; and the 21 rats that had 14 days of ethanol inbubations ending no more than 2 days before the test showed the least aversion. Variations in accessibility of water had no significant effect on consumption of saccharin. The possibility of the development of tolerance to ethanol during the preconditioning period is discussed.

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