SubTenon Injection of Gentamicin for Bacterial Infections of the Eye

Publisher Website
Google Scholar
Abstract
Bacterial infection of the eye presents unique problems. Protease-producing bacteria such as Pseudomonas may cause perforation of the globe in less than a day. With intraocular infections, it is very difficult to obtain adequately high levels of antibiotics so that minimal inhibitory concentrations are reached within the ocular tissues. Measurements are presented for the free, microbiologically active gentamicin administered by subTenon or intramuscular injections, or by both routes, in inflamed and noninflamed eyes. In rabbits' eyes, adequate levels of gentamicin may be obtained with the subTenon administration of 20 mg of the drug every 24 hr. The level of intraocular antibiotics is raised by the simultaneous subTenon and intramuscular administration of gentamicin.

This publication has 0 references indexed in Scilit: