Reported Neurologic Disorders Following Live Measles Vaccine

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Abstract
In the 26 months from January 1965 through February 1967, 23 instances of neurologic disorder following measles vaccination were reported to the National Communicable Disease Center. Analysis of data for individual cases reveals that one was probably caused by herpes simplex and three (possibly four) patients had no serologic response to vaccination. In no case was it possible to determine whether the illness was actually vaccine induced or whether the temporal association with vaccine inoculation was merely coincidental. That 23 known cases of encephalitis have been reported indicates the need for active surveillance of all suspect cases. However, it is obvious that the risk of encephalitis is much greater after the natural disease than after vaccination.

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