DISCREPANCY BETWEEN RENIN mRNA AND PLASMA RENIN LEVEL IN ANGIOTENSIN‐CONVERTING ENZYME INHIBITOR‐TREATED RATS

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Abstract
1. To investigate the role of transcriptional and post‐transcriptional factors in increasing renin synthesis secondary to angiotensin‐converting enzyme (ACE) inhibitors, we studied the changes in levels of renal renin mRNA, plasma renin and other hormonal factors. 2. Spontaneously hypertensive rats were orally administered 10 mg/kg spirapril or vehicle daily for 3, 14 or 28 days. 3. Plasma renin activity in the spirapril‐treated group was significantly elevated compared with that in the vehicle group at any time (PPPP<0.01). 6. Our study demonstrated a non‐proportional change in plasma renin and renal renin mRNA levels. It is suggested that the main determinant of the rate of renin synthesis after administration of an ACE inhibitor may be post‐transcriptional factors, and that unknown mechanisms may be involved in the increase in plasma renin level after long‐term administration of ACE inhibitor in addition to the short feedback mechanism brought about by the decrease in angiotensin II.