The concept of lymphogranuloma venereum as a systemic infection rather than a local one is of fairly recent origin. Beginning with the report of Durant, Nicholas and Favre1 in 1913, evidence has accumulated in support of this view. Van Rooyen and Rhodes2 stated that, in addition to the more frequent involvement of genitalia and regional lymph glands, lymphogranuloma venereum may manifest itself by involvement of the throat, with inflammation of the tonsils, ulcerations or angina, by fever, with headaches and other pyrexial disturbances, by cutaneous rashes, by various forms of articular involvement, by generalized involvement of the lymph nodes, with splenomegaly and hepatomegaly, by granulomatous conjunctivitis, by epididymitis and by meningoencephalitis. In 1936 von Haam and D'Aunoy3 reported the isolation of the virus from the spinal fluid of 2 patients during the acute stage of the infection, when the cerebral manifestations consisted mainly of headaches. Rajam4