Transplantation immunity in the isologous mouse radiation chimaera.

  • 1 July 1960
    • journal article
    • Vol. 3  (3) , 195-213
Abstract
The survival of skin homo- and heterografts on isologous CBA mouse chimaeras has been investigated. Homografts usually persist for considerably longer than on normal unirradiated mice. Immunization of the host against the appropriate foreign antigens before irradiation neither reduces nor increases the duration of this persistence. When an irradiated non-immune host is restored with bone marrow from an immunized donor, a measure of immunity is transferred.