Inhibition of Hepatocellular Carcinomas in vitro and Hepatic Metastases in vivo in Mice by the Histone Deacetylase Inhibitor HA-But
Open Access
- 15 July 2004
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 10 (14) , 4822-4830
- https://doi.org/10.1158/1078-0432.ccr-04-0349
Abstract
Purpose: The purpose is to evaluate the CD44-mediated cellular targeting of HA-But, a hyaluronic acid esterified with butyric acid (But) residues, to hepatocellular carcinoma cell lines in vitro and to hepatic tumor metastases in vivo.Keywords
This publication has 21 references indexed in Scilit:
- Hyaluronic-acid butyric esters as promising antineoplastic agents in human lung carcinoma: A preclinical studyInvestigational New Drugs, 2004
- Prognostic value of disseminated colorectal tumor cells in the liver: results of follow-up examinationsInternational Journal of Colorectal Disease, 2004
- Liver Metastasis at the Time of Initial Diagnosis of Lung CancerMedical Oncology, 2003
- Changes in serum hyaluronic acid levels and expression of CD44 and CD44 mRNA in hepatic sinusoidal endothelial cells after major hepatectomy in cirrhotic ratsWorld Journal of Surgery, 2002
- Surgical treatment of hepatic metastases from breast cancerBreast Cancer Research and Treatment, 2000
- A Phase I/II Study of Continuous Intra-arterial Chemotherapy Using an Implantable Reservoir for the Treatment of Liver Metastases from Breast Cancer: A Japan Clinical Oncology Group (JCOG) Study 9113Japanese Journal of Clinical Oncology, 1999
- The YAP camera: an accurate gamma camera particularly suitable for new radiopharmaceuticals researchIEEE Transactions on Nuclear Science, 1997
- Butyrate inhibits seeding and growth of colorectal metastases to the liver in miceSurgery, 1996
- Functions of hyaluronan.Annals of the Rheumatic Diseases, 1995
- Labelling of high molecular weight hyaluronan with125I-tyrosine: studiesin vitro andin vivo in the ratGlycoconjugate Journal, 1994