Inhibition of Lecithin:Cholesterol Acyltransferase in Human Plasma by Dicarboxylic Lecithins

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Abstract
The effect of dicarboxylic lecithins on the lecithin:cholesterol acyltransferase (LCAT) activity was studied with a partially purified preparation (approximately 24-fold). The presence of dicarboxylic lecithins is followed by the inhibition of LCAT. The inhibition is proportional to the concentration of glutaryl-lecithin and is about 50% with 0.16 mM glutaryl-lecithin. For a higher concentration, the inhibition is total. The inhibition of LCAT activity was of a mixed type. It can be explained by a combination of competitive inhibition and interaction of glutaryl-lecithin with phospholipid, which changes the physical properties of lipid, making it less available for conversion into cholesteryl ester.