Resolution of enantiomers of ibuprofen by liquid chromatography: a review

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Abstract
Ibuprofen is one of the most effective and widely used non‐steroidal analgesic and anti‐inflammatory agent. It is marketed as a racemic mixture though it is known that the pharmacological activity resides in the (S)‐(+)‐enantiomer only. Several direct/indirect liquid chromatographic methods involving a variety of chiral/achiral phases along with their possible role in resolution, chiral and achiral agents used for derivatisation have been discussed with special reference to ibuprofen, and mentioning their application to the resolution of other 2‐aryl‐propionic acids/profens. Copyright © 1998 John Wiley & Sons, Ltd.

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