Maduropeptin, a complex of new macromolecular antitumor antibiotics.
- 1 January 1991
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 44 (4) , 403-414
- https://doi.org/10.7164/antibiotics.44.403
Abstract
Maduropeptin, a complex of new macromolecular antitumor antibiotics, is a metabolite of Actinomadura madurae H710-49. The active components maduropeptins A1, A2 and B are acidic chromopeptides with MW of around 22,500 and composed of 14 types of amino acids and an unstable chromophore. The antibiotics are active in vitro against Gram-positive bacteria and highly cytotoxic to tumor cells. They produced significant prolongation of survival time of mice implanted with P388 leukemia and B16 melanoma.Keywords
This publication has 0 references indexed in Scilit: