Tricyclic Antidepressants: Evidence for an Intraneuronal Site of Action
- 25 April 1969
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 164 (3878) , 437-439
- https://doi.org/10.1126/science.164.3878.437
Abstract
Desipramine, a tricyclic antidepressant drug, almost completely prevents the accumulation of tritiated norepinephrine by sympathetic neurons of the rat heart after the injection of a tracer dose of the labeled amine. However, desipramine does not alter the accumulation of norepinephrine after the injection of a large dose of the neurohormone. Despite the failure of desipramine to block the neuronal uptake of norepinephrine, it still prevents exogenous norepinephrine from displacing the endogenous neurohormone (previously labeled with H3-norepinephrine) from intraneuronal storage sites.Keywords
This publication has 15 references indexed in Scilit:
- Uptake of Some Tritiated Sympathomimetic Amines by Mouse Brain Cortex Slices In VitroActa Pharmacologica et Toxicologica, 1966
- Studies in vitro of amine uptake mechanisms in heartBiochemical Pharmacology, 1966
- Catecholamine metabolism in affective disorders: I.Journal of Psychiatric Research, 1965
- ON THE MECHANISM OF ACTION OF GUANETHIDINE AND BRETYLIUMBritish Journal of Pharmacology and Chemotherapy, 1965
- Direct Demonstration of the Systems of Terminals Belonging to an Individual Adrenergic Neuron and Their Distribution in Rat IrisActa Physiologica Scandinavica, 1965
- Mechanism of Amine Transport in the Cell Membranes of the Adrenergic NervesActa Pharmacologica et Toxicologica, 1965
- Excretion of 3-methoxy-4-hydroxymandelic acid (VMA) in depressed patients treated with antidepressant drugsJournal of Psychiatric Research, 1964
- Reserpine and cocaine blocking of the uptake and storage mechanisms in adrenergic nervesLife Sciences, 1964
- ON THE MECHANISM OF ANTIDEPRESSANT ACTION OF IMIPRAMINELIKE DRUGSAnnals of the New York Academy of Sciences, 1962
- Effects of Drugs on Uptake of Isotopic Norepinephrine by Cat TissuesNature, 1961