The Nature of C-Reactive Protein in Acute Phase Serum: Evidence for an Equilibrium form Containing a Mucopolysaccharide of Serum
Open Access
- 1 March 1967
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 98 (3) , 521-528
- https://doi.org/10.4049/jimmunol.98.3.521
Abstract
Summary: C-reactive protein (CRP) in acute phase serum is in equilibrium with mucopolysaccharide, also present in normal serum, to form a higher molecular weight mucopolysaccharide-CRP complex. The interaction, in part, involves participation of sialic acid. CRP purified by chromatography on diethylaminoethyl (DEAE)-cellulose, or partially purified by the procedure of Wood et al. (3), contains mucopolysaccharide. Addition of a final gel filtration step on Sephadex G200 to purified CRP isolated by chromatography on DEAE-cellulose yields readily crystallizable CRP, and the interacting mucopolysaccharide.This publication has 1 reference indexed in Scilit:
- The Chemical Composition of Pneumococcal C-PolysaccharideJournal of Biological Chemistry, 1963