Clinical Characteristics of Acromegalic Patients whose Pituitary Tumors Contain Mutant GsProtein
- 1 December 1990
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 71 (6) , 1416-1420
- https://doi.org/10.1210/jcem-71-6-1416
Abstract
Activating mutations in the gene for the .alpha.-chain of Gs, the stimulatory regulator of adenylyl cyclase, have been identified in human GH-secreting pituitary tumors. Using the polymerase chain reaction and allele-specific oligonucleotide hybridization, we screened 25 GH-secreting tumors for the presence of the activating mutations. We also reviewed the clinical charts of the patients from whom the tumors were removed. Of 25 tumors, 10 (40%) contained activating mutations. Patients in the mutation-positive group came to surgery with smaller tumors and had lower GH levels. The activating mutations identify a subgroup of GH-secreting pituitary tumors that probably arise from a shared oncogenic mechanism.This publication has 3 references indexed in Scilit:
- Two G Protein Oncogenes in Human Endocrine TumorsScience, 1990
- ras GENESAnnual Review of Biochemistry, 1987
- Growth hormone-releasing factor stimulates proliferation of somatotrophs in vitro.Proceedings of the National Academy of Sciences, 1986