Pityriasis rubra pilaris. Treatment with folic acid antagonists

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Abstract
Four patients with pityriasis rubra pilaris were treated with the oral form of folic acid antagonists (aminopterin and metho-trexate) for an average duration of 12 months. Marked clinical improvement was noted in all four patients. Two patients have discontin ued therapy for periods of 24 and 7 months and have not had a recurrence of their disease. The pharmacology of f olic acid antagonists and the rationale for their use in the treatment of pityriasis rubra oilaris are briefly discussed.

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